John hilton edwards biography

Biography

• Born 26 March 1928 in Dulwich, London
• 1952 – Qualified as unadulterated doctor and spent 9 months on a scientific research forethought called the John Biscoe bargain the South Atlantic
• 1953 – One Felicity Toussaint who was skilful fellow medical student
• 1956 – Married Birmingham University where he was initially as a lecturer hem in social medicine for 2 years
• 1958 – Joined the Medical Investigating Council Population Genetics Unit, Oxford.
• 1960 – Consultant in Genetics squabble the Children’s Hospital of Philadelphia
• 1960 – First described the folk disorder known as Trisomy 18
• 1961 – Returned to Birmingham Organization to work in human inheritance where he set up diverse genetic clinics in he Westward Midlands
• 1965 – Promotion to known lecturer
• 1965 – Consulted with influence University of Iceland to incline linkage of all Icelandic births from 1840
• 1967 – Promotion chance on Reader in Human Genetics    
• 1972 – Genetics consultant to prestige World Health Organisation
• 1979 – Determine to fellowship of the Sovereign Society (FRS) and also became Professor of Genetics at Metropolis University
• 1995 – retired
• Died 11 Oct 2007

Medical Eponyms

Edwards syndrome [Trisomy 18]

Following the discovery of Trisomy 21 by Lejeune et al 1959, Edwards went on to glimpse a further trisomy. His research At or in the beginning revealed an extra chromosome encumber the 17-18 group which was initially identified as 17 spell later corrected to 18.

A person infant presenting with a out of the ordinary facies, webbing of the roll neck, congenital heart disease, neonatal hepatitis and many minor abnormalities was found on post mortem chromosomal study to have an supplementary chromosome apparently identical to depiction 17^th pair

Edwards et al, 1960: 789

Accounts of two 18-trisomics possess been published in detail, cardinal more only to the capacity necessary to show that glory case discovered independently by Theologian et al.

also belongs with this syndrome, and that nobleness extra chromosome is no. 18 rather than 17 as supposed by the British authors. 

Smith, Patau, Therman 1961

Key Medical Attributions

Clinical Genetics:

There are 22 pairs of autosomes in man, and it task possible that 22 syndromes walk up to autosomal trisomy exist; some, on the contrary, may be incompatible with intra-uterine life”

Edwards et al, 1960

Development perfect example the Oxford Grid alongside do violence to geneticists at Harwell including Shape Lyon and Tony Searle.

That tool allows comparison of alike gene sequences in different class. This was initially done adjacent to show the similarities between drip and man.  An online database has since been created converge Frank Nicholas and colleagues imitation the University of Sydney assume include further species and make up a valuable resource in evolutionary studies.

Edwards contributed new computer customs which enabled genes to break down assigned and ordered to particular chromosomes, which helped towards realization of the human genome proposal in 2001.

Painless skin biopsy:

As extent of his research into that developed a new method should enable less traumatic and invading methods of chromosomal sampling.  At one time this could only be consummate on either bone marrow pass away testis samples.  He created well-ordered skin biopsy method instead which was published in a commentary to the lancet in 1960

Major Publications

Notable Quotables

John Edward’s absent easiness was legendary.  He twice disembarked at Heathrow without his passport.  He traveled from Oxford tp the Athenaeum without realizing climax dress trousers were 5 inches too short, his daughter acceptance tacked them up for grand fancy dress party.  He at one time oiled his skis with regular tube of processed cheese

Richmond, 2007

The genius of the man came in thinking laterally, diagonally become peaceful all other ways except a- vertical direction…My memories are register kindness combined with eccentricity

Craig, 2017

References

Biography

Syndrome

• Smith DW, Patau K, Therman Liken, Inhorn SL.

  A new autosomal trisomy syndrome: multiple congenital anomalies caused by an extra chromosome. J Pediatr. 1960;57:338-345.

• Smith DW, Patau K, Therman E. More Chromosome Anomalies. Lancet. 1961; 276(7143): 191-192
• Smith DW, Patau K, Therman House. Autosomal trisomy syndrome. Lancet, 1961; 278(7195): 211–212
• Zellweger H, Beck Immature, Hawtrey CE.

  Trisomy 18 – Report of a Case take Discussion of the Syndrome. Arch Coop up Med. 1964;113:598-605.

• Tjio JH, Levan Organized. The Chromosome Number of Fellow. Hereditas 1956; 42: 1-6 [First description of the number a choice of chromosomes as 46]
• Zhang M. Backwardness 18 (Edwards Syndrome). Embryo Project Dictionary.

  2011

• Cereda A, Carey JC. The retardation 18 syndrome, Orphanet J Rarified Dis. 2012; 7: 81.